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Spread over 1200 acre of land, the University of Karachi was established through the parliament as a Federal University in 1951. However, through another act of the parliament in 1962 its status was redefined as university of the province of Sindh. On 23rd October, 1950 the Karachi University Act was passed and after an amendment in 1951 it was enacted and Prof A.B.A Haleem was appointed as its first Vice Chancellor. For the first two years, the University of Karachi remained as an examination University for the affiliated colleges. In the year 1953 it started its teaching and research activities at two Faculties of Arts and Science. Opened with an initial intake of 50 students, the university is now a sprawling structure of 53 Departments and 20 world class and highly reputable Research Centers and Institutes, under eight faculties of Arts, science Islamic Studies Pharmacy Commerce & Business Administration, Law, Education and Medicine. At present the enrolment of a regular student at the Campus is slightly over 24,000. There are about 700 teachers and more than 2500 supporting staff.

Karachi University always proudly mentions the names of renowned educationists and scholars associated with this institution of higher learning like, Dr. I. H. Qureshi, Dr. Mahmud Hussain, Dr. Salemuzzaman Siddiqui, Dr. Afzal Hussain Qadri, Dr. M. M. Ahmed , Dr Mujtaba Karim, Prof. M. Ilyas, Prof. Q. Fareed, Dr. Ibadur Rehman Khan, Prof Muntakhib ul Haq, Prof. Memony, Dr. S. M. Yousuf, Dr. M.A Wali, Dr. Karawala. The faculty was drawn not only from Pakistan but also included eminent educationists form Europe and America.

In pursuance of acquiring excellence in research, faculty of the University has been actively involved in supervising research projects, results of which are being accepted and published in top quality journals of international repute. In 2007-08 alone, the faculty of the University of Karachi has published more than 700 research papers in peer-reviewed journals indexed by Thomson-Reuter (ISI Web of knowledge) and ranked at number two among 60 Universities/ Institutions (public and private sectors) of Pakistan. The alumni of the University are holding key positions in various prestigious national and international organizations.

The Karachi University today is the biggest university of in the country. It comprises eight faculties with which all the colleges of the city are affiliated B.S, M.S, M.Phil and Ph.D classes under five of these faculties Arts, Science, Pharmacy, Commerce and Islamic Learning are conducted on the campus, while under the Faculties of Medicine, law and Education it examines the students admitted to their affiliated colleges. Research programmers leading to M.Phil and Ph.D Degree are offered under all the faculties.

Science

The Science Faculty which consists of 23 departments and five research Institutes can be said to be the biggest scientific centre in the country. The Research Institutes include the HEJ Research Institute of Chemistry, which is world renowned and has also been designated World Academy of Science. It is the prime research institutes of the country and has high level research faculties for chemical science particularly Natural Product Chemistry.

Other Institutes are Dr. Punjwani Centre for Molecular Medicines and Drug Research, Khan Institutes if Biotechnology and Genetic Engineering, Dr Afzal Hussain Qadri Biological Research Centre, which is a common research facility for all the biological science departments; the Marine Resources Collection and Research Centre, which is the biggest repository of marine life from the Arabian Sea. National Nematological Research Centre, which undertakes research in plant pest control. Centre of Excellence in Marine Biology, a federally founded centre for the study of marine fauna of the Arabian Sea; the Institute of Environmental Studies, Institute of Molecular Genetics and Umair Basha Institute of Information Technology which is going to become operational after up gradation of the present department of Computer Science.

Scholars

It is noteworthy that the number of M.Phil/Ph.D in science produced by the Karachi University far exceeds the number produced in any other university of the country. So far, about 600 M.Phil, 300 Ph.D, 7 D.Sc and 7 D.Litt. degrees in Science have been awarded by the university. The University teachers are also involved in various research projects and contribute regularly to publications of home and abroad. Only in 2006 the number of published research papers by the reaching and research faculty of the university is 506.